Impaired lexical access for unique entities in individuals with subjective cognitive decline.

Subjective cognitive decline (SCD) may serve as an early indicator of Alzheimer's disease (AD). However, accurately quantifying cognitive impairment in SCD is challenging, mainly because existing assessment tools lack sensitivity. This study examined how tasks specifically designed to assess knowledge of famous people, could potentially aid in identifying cognitive impairment in SCD. A total of 60 adults with SCD and 60 healthy controls (HCs) aged 50 to 82 years performed a famous people verbal fluency task and a famous people naming task. In the famous people fluency task, the results showed that the individuals with SCD produced significantly fewer famous names in the total time allowed than the HCs, and this difference was also found in the first and the second time interval. In the famous people naming task, the performance of the SCD group was significantly lower than that of the HC group only in the more recent period of fame. Overall, these results suggest that retrieving the names of famous people was more difficult for people with SCD than for people without cognitive complaints. They also suggest that famous people verbal fluency and naming tasks could be useful in detecting cognitive decline at the preclinical stage of AD.

The Quebec Semantic Memory Battery: Development, Standardization, and Psychometric Assessment of a Semantic Memory Battery in French.

OBJECTIVE: People with aphasia often experience semantic memory (SM) impairment. To improve diagnostic outcomes, SM tasks should recruit various sensory input channels (oral, written, and pictographic), permitting accessible, complete evaluation. There is a need for SM batteries for French-speaking Quebecers that use multiple input channels. The present study, therefore, describes the development of a novel French-language semantic battery: la Batterie québécoise de la mémoire sémantique (BQMS), the assessment of the BQMS's psychometric properties, and the establishment of normative data for the BQMS. METHOD: We first developed eight SM tasks. Following a pilot validation study, we determined the BQMS's reliability and validity, to ensure consistent, accurate detection of SM impairment. Among French-speaking Quebecers with cerebrovascular aphasia (n = 10), people with the semantic variant of Primary Progressive Aphasia (n = 4), and healthy controls (n = 14), we examined its convergent validity, concurrent validity, test-retest reliability, and internal consistency. Finally, we established normative data for the BQMS by calculating cut-off scores per task that indicate SM impairment (in 93 cognitively healthy French-speaking Quebecers), stratified by sociodemographic variables associated with performance. RESULTS: The BQMS shows high concurrent, discriminant, and convergent validity, as well as good test-retest reliability and internal consistency. The cut-off score indicating SM impairment ranged from the 2nd to 25th percentiles (stratified by task, age, and sex). CONCLUSIONS: The BQMS's psychometric properties indicate that it could be a valuable clinical tool for detecting SM impairment. Our normative data will help clinicians detect such impairments.

The DDQ-30, a new naming-from-definition test: Normative data for the adult French-Quebec population and validation study in mild cognitive impairment and Alzheimer's disease.

Assessing naming abilities is a standard clinical procedure for adults and is usually carried out using picture naming tests. However, the use of picture naming tests can have limitations, as people may have visual impairments that can affect the validity of the measurement. This article introduces the DDQ-30, a new naming-from-definition test for detecting anomia in people with visual-perceptual limitations. The article describes three studies. Study 1 focused on the developmental phase of the DDQ-30. In Study 2, healthy participants and individuals with mild cognitive impairment or Alzheimer's disease were assessed with the DDQ-30 to determine its predictive validity. Study 3 examined a group of adults and older French-speaking Quebecers to obtain normative data. The DDQ-30 effectively differentiated between AD and healthy participants. In addition, normative data were collected on 251 participants aged 50 years and older. Analyses showed that age and educational level were significantly related to performance on the DDQ-30. The DDQ-30 fills an important gap and promises to help clinicians and researchers better detect anomia in people with visual impairment.

The symptoms of surface dyslexia in Arabic: the impact of orthographic ambiguity on reading abilities of a patient with Alzheimer's disease.

Like other Semitic languages, Arabic is known for its rich morphology and consonantal writing system. In this article, we report the first case of acquired surface dyslexia in an Arabic-speaking patient (HBS). Surface dyslexia is characterised by difficulty reading irregularly spelled words, while performance is better with regular words and nonwords. The purpose of this study was to describe the symptoms of surface dyslexia in Arabic and to investigate how orthographic depth may affect reading in the context of semantic impairment. In HBS, who had Alzheimer's disease, reading was impaired for both words and nonwords. Her reading performance was affected by orthographic ambiguity and by the presence of diacritics depicting short vowels. In particular, she produced mainly vowel errors, suggesting an overreliance on the sublexical route of reading. On the other hand, HBS was able to distinguish long vowels from consonants represented by the same letters, provided there was a real root. This finding can be taken as evidence that HBS could access the word's root to decide whether the vowel letter represents a long vowel or a consonant. The results of this study suggest that the characteristics of surface dyslexia appear to be universal: reading regular words is spared compared to irregular words and non-words. However, the error patterns that HBS showed in reading support a language-specific conceptualisation of the processing components of the lexical and sublexical routes of reading.

Turkish adaptation, reliability, and validity of the detection test for language impairments in adults and the aged.

There is no quick, valid, and reliable screening tool in Turkish that can be used for screening language disorders associated with major neurocognitive disorders (MND). To fill this gap, we designed three distinct studies. In the first study, we adapted the Detection Test for Language Impairments in Adults and the Aged into the Turkish language (DTLA-Tr). In the second study, we collected data from 175 Turkish individuals to determine the normative data of the DTLA-Tr. In the last study, we investigated the psychometric properties of the DLTA-Tr by comparing 17 healthy individuals with 17 patients with Alzheimer's disease and determining its test-retest reliability. As a result of Study 1, the DTLA was adapted to the Turkish adult population. In Study 2, the normative data of the DTLA-Tr were provided. The results of this study indicated a positive correlation between educational level and DTLA-Tr total score. The results of Study 3 showed that the DTLA-Tr has high predictive validity and good test-retest reliability. The DTLA-Tr is a valid and reliable tool for assessing language abilities in both adults and the elderly. The findings of this study have significant implications for the evaluation of language in Turkish-speaking patients with MND.

Language Impairment in Vascular Dementia: A Clinical Review.

Vascular cognitive impairment (VCI) encompasses a wide range of conditions, including cognitive impairment associated with stroke or vascular brain injury, mild vascular cognitive impairment, and vascular dementia (VD). Knowledge of language impairment associated with VD is far less extensive than that of Alzheimer's disease. Although not prevalent in VD, impairment in language skills has been reported. A better understanding of the neurolinguistic features associated with the different presentations of VD could facilitate medical diagnosis. In this article, we report data on language impairment in VD, with particular attention to their primary or secondary functional origin. To better appreciate this functional origin, we also outline the main characteristics of impairment in other cognitive functions. Key elements that should be considered in the speech-language assessment of individuals with possible or proven VD are also highlighted.

Normative Data for the Judgment of Line Orientation Test (Long and Short Forms) in the Quebec-French Population Aged between 50 and 89 Years.

The Judgment of Line Orientation (JLO) Test of Benton assesses visuospatial processing without requiring motor skills. The test is frequently used in geriatric or brain-injured populations. As with other cognitive tests, performance on the JLO test may vary according to age, level of education, sex, and cultural background of individuals. The present study aimed to establish normative data for a short (15 items) and a long (30 items) form of the JLO. The sample for the short and long forms comprised 198 and 260 individuals, respectively, aged 50-89 years. All participants were French-speaking people from the province of Quebec, Canada. Using regression-based norming, the effects of age, years of formal education, and sex on JLO performance were estimated. The normative adjustment of the JLO short and long forms considered the weight of each predictor on test performance. Results indicated that JLO performance was positively associated with years of formal education and male sex, whereas it was negatively associated with age. Accordingly, normative data were generated using Z-scores and adjusted scaled scores derived from the regression equations. To conclude, the present norms will ease the detection of visuospatial impairment in French-Quebec middle-aged and older adults.

Normative Data for the Alternating and Orthographic Constraint Semantic Fluency Tests in the Adult French-Quebec Population and Validation Study in Mild Cognitive Impairment and Alzheimer's Disease.

Verbal fluency tests, known to elicit executive functions (EFs), have proven useful in distinguishing healthy individuals from those with cognitive impairment. The present study addresses two new tests of verbal fluency that elicit EFs, namely, extradimensional alternating fluency (EAF) and extradimensional orthographic constraint semantic fluency (EOCSF). The aim of Study 1 was to provide normative data in the adult and elderly population of French Québec for the two fluency tests. The aim of Study 2 was to determine their psychometric value. The normative sample consisted of 338 healthy controls (HCs) aged 50-89 years. Multiple linear regressions were used to generate equations for calculating Z-scores. Convergent validity was established by administering the two verbal fluency tests and the Letter-Number Sequence (LNS) subtest of the WAIS-III. To assess predictive validity, the performance of 19 HCs was compared with that of 19 participants with mild cognitive impairment (MCI) and 19 participants with Alzheimer's disease (AD). To determine test-retest reliability, the test was administered twice, 3 months apart, to a subsample of 20 HCs. Age and educational level were significantly related to performance in the EAF and the EOCSF. The two tests correlated significantly and positively with the LNS. The EAF and the EOCSF distinguished the performance of HCs from that of participants with MCI or AD. A test-retest analysis showed that scores on the two tests were stable over time. The norms and psychometric data for the EAF and the EOCSF will help clinicians and researchers better identify executive impairments associated with pathological conditions.

The impact of phonological short-term memory impairment on verbal repetition in the logopenic variant of primary progressive aphasia.

The logopenic variant of primary progressive aphasia (lvPPA) is characterized mainly by anomia, production of phonological errors, and impairment in repetition of sentences. The functional origin of these language impairments is mainly attributed to the breakdown of phonological short-term memory. The present study examined the effects of phonological short-term memory impairment on language processing in lvPPA. In two studies, 11 participants with lvPPA and 11 healthy control participants were presented with repetition tasks in which the type and length of stimuli and the mode of administration were manipulated. Study 1 aimed to examine the influence of length and lexicality (words vs. pseudowords) on immediate and delayed repetition, whereas Study 2 aimed to examine the influence of length, syntactic complexity (nominalized vs. pronominalized sentences), and serial position on immediate sentence repetition. Study 1 showed that participants' performance with lvPPA was impaired only on immediate repetition of five-syllable pseudowords and on delayed repetition of words and pseudowords. Study 2 showed that participants' performance with lvPPA was impaired in the repetition of nominalized sentences where a recency effect was observed. Repetition of pronominalized sentences was also impaired in the lvPPA group. This study provides additional support for arguments regarding phonological short-term memory as a cause of language impairment in lvPPA. Clinically, the results of the study suggest that instruments for assessing repetition ability in lvPPA should include not only lists of short or long nominalized sentences, but also delayed repetition of words and pseudowords and pronominalized sentences.

Normative data for the Tower of London (Drexel version) in the Quebec-French population aged between 50 and 88 years.

The Tower of London (ToL) is a neuropsychological test used to assess several executive functions such as strategical reasoning, mental planning, and problem-solving. Like other cognitive tests, performance on the ToL can vary according to age, level of education, sex, and cultural background of individuals. The present study aimed to establish normative data for the Drexel version of the ToL among French-Quebec people aged 50 years and over. The normative sample consisted of 174 healthy individuals aged 50-88 years, all from the province of Quebec, Canada. Analyses were performed to estimate the associations between age, sex, and education level on one hand, and ToL performance, on the other hand. Results indicated that Total Execution Time was associated with age, whereas the Total Type II Errors and Total Rule Violation score (Type I + II Errors) were associated with both age and education level. All other scores were not significantly associated with the demographic characteristics of the participants. Since the distributions of the data were all skewed, the normative data are presented in the form of percentile ranks. To conclude, the present norms will ease the detection of executive impairments in French-Quebec middle-aged and older adults.

Normative data for the 12-item Buschke memory task in the Quebec-French population aged 50 and over.

OBJECTIVE: The 12-item Buschke memory test is used to assess verbal episodic memory in adults and older adults. However, there is no normative data for this test adjusted to the older Quebec-French population. The aim of the study was to produce normative data for the 12-item Buschke for the Quebec-French population aged 50 and older. METHOD: The normative sample consisted of 172 healthy French-speaking participants aged 50-89 years, from the Province of Quebec (Canada). The influence of age, years of formal education, and sex on five 12-item Buschke scores were analyzed. Based on the distribution of scores, normative data were developed as Z-scores equation, regression equation, and percentiles. RESULTS: Age, years of formal education, and sex were all associated with performance. Equations to calculate Z-scores were provided for the free recall trial 1 and the free recall trials 1-3. Stratified percentiles were provided for the delayed free recall and total recall 1-3. CONCLUSIONS: The normative data for the 12-item Buschke improve the accuracy of clinicians to detect verbal episodic memory impairments in Quebec's aging population.

Normative data for the verb fluency test in the adult French-Quebec population and validation study in mild cognitive impairment.

Verbal fluency tests are used to assess executive functions and language. The verb fluency test has proven successful in distinguishing healthy individuals (HCs) from participants with pathological conditions. However, few normative and psychometric studies have been published for the verb fluency test. The aim of Study 1 was to provide normative data in the adult population of French Québec for the verb fluency test. The aim of Study 2 was to determine its discriminant validity and test-retest reliability. The normative sample consisted of 424 HCs aged 50-92 years. Multiple linear regressions were used to generate equations for calculating Z-scores. To assess discriminant validity, the performance of 46 HCs was compared with that of 46 participants with mild cognitive impairment (MCI). To determine test-retest reliability, the test was administered twice, 3 months apart, to a group of 25 HCs. Age, sex, and education level were significantly related to performance on the test. The test distinguished the performance of HCs from that of participants with MCI. Test-retest analysis showed that scores had good stability over time. Norms and psychometric data for the verb fluency test will help clinicians and researchers better identify executive and language impairments associated with pathological conditions.

Preliminary Validation Study of the French-Quebec Version of the Mild Behavioral Impairment Checklist.

BACKGROUND: Alzheimer disease dementia may be preceded by cognitive stages during which behavioral and psychological changes can occur. More precisely, behavioral symptoms may be observed during the subjective cognitive decline (SCD) or the mild cognitive impairment (MCI) stages; these symptoms can be measured using the Mild Behavioral Impairment Checklist (MBI-C). OBJECTIVE: To validate the French-Quebec version of the MBI-C in individuals ages 60-85 years. METHOD: The sample included 60 participants (20 MCI, 20 SCD, 20 cognitively healthy) and their informants. To assess the discriminant validity of the MBI-C, a Kruskal-Wallis analysis with a multiple comparisons test was performed on the MBI-C Total score. To determine convergent validity, Spearman correlations were calculated between the MBI-C subscales and a set of validation tools. Finally, test-retest reliability was assessed with Spearman correlations of MBI-C scores between two test sessions. RESULTS: All of the analyses indicated satisfactory psychometric properties for the French-Quebec version of the MBI-C. CONCLUSION: This validation study reveals that the MBI-C can be used successfully in dementia risk assessments. From now on, the use of a validated MBI-C will be possible in the French-Quebec population.

The Use of Executive Fluency Tasks to Detect Cognitive Impairment in Individuals with Subjective Cognitive Decline.

OBJECTIVE: Although evidence has indicated that subjective cognitive decline (SCD) may be an early sign of Alzheimer's disease (AD), the objectification of cognitive impairment in SCD is challenging, mainly due to the lack of sensitivity in assessment tools. The present study investigated the potential contribution of two verbal fluency tasks with high executive processing loads to the identification of cognitive impairment in SCD. METHODS: A total of 60 adults with SCD and 60 healthy controls (HCs) performed one free action (verb) fluency task and two fluency tasks with more executive processing load-an alternating fluency task and an orthographic constraint fluency task-and the results were compared. RESULT: In the free action fluency task, the performance of the participants with SCD and the HCs was similar. However, HCs performed significantly better than SCD in the alternating fluency task, which required mental flexibility, and the orthographic constraint fluency task, which required inhibition. DISCUSSION: The study findings suggest that verbal fluency tasks with high executive processing load could be useful in detecting cognitive deficits at the preclinical stage of AD. The inclusion of such tests in assessment batteries should be considered in order to improve the detection of subtle cognitive impairment in preclinical major neurocognitive disorder populations.

Normative data for the Color Trails Test in middle-aged and elderly Quebec-French people.

OBJECTIVE: Despite the widespread use of the Color Trails Test (CTT) in clinical and research settings, information regarding the impact of sociodemographic variables on test performance in Quebec-French adults and elderly people is non-existent. This study aimed to establish French-Quebec normative data for error scores and completion time on all test trials (CTT1 and CTT2) taking into account the impact of age, education, and sex on test performance. METHOD: The sample consisted of 169 community-dwelling and healthy Quebec-French individuals aged between 50 and 90 years and having between 6 and 21 years of formal education. RESULTS: Regression analyses indicated that age was associated with completion time on CTT1 and CTT2. Spearman correlations also revealed that age was positively associated with error scores (CTT1 errors, CTT2 number errors, CTT2 near-misses) and index interference. Education was marginally associated with CTT1 but was not associated with CTT2 completion time or interference index. Education was only associated with the number of errors in the CTT2. Finally, sex was not associated with any variables. Equations to calculate Z scores and percentiles are presented. CONCLUSIONS: Norms for the CTT will ease the interpretation of executive functioning in Quebec-French adults and the elderly and favor accurate discrimination between normal and pathological cognitive states.

The Orthographic Ambiguity of the Arabic Graphic System: Evidence from a Case of Central Agraphia Affecting the Two Routes of Spelling.

The Arabic writing system includes ambiguities that create difficulties in spelling. These ambiguities relate mainly to the long vowels, some phoneme-grapheme conversions, lexical particularities, and the connectivity of letters. In this article, the first to specifically explore acquired spelling impairments in an Arabic-speaking individual, we report the case of CHS, who presented with agraphia following a stroke. Initial testing indicated substantial impairment of CHS's spelling abilities in the form of mixed agraphia. The experimental study was specifically designed to explore the influence of the orthographic ambiguity of the Arabic graphemic system on CHS's spelling performance. The results revealed that CHS had substantial difficulties with orthographic ambiguity and tended to omit ambiguous graphemes. Some of the errors she produced suggested reliance on the sublexical route of spelling, while others rather reflected the adoption of the lexical-semantic route. These findings from a case involving a non-Western, non-Indo-European language contribute to discussions of theoretical models of spelling. They show that CHS's pattern of impairment is consistent with the summation hypothesis, according to which the lexical-semantic and the sublexical routes interactively contribute to spelling.

Normative data for the story recall subtest of the BEM-144 in the Quebec-French population aged 50 years and over.

OBJECTIVE: The story recall subtest of the Batterie d'Efficience Mnésique (BEM-144) is a verbal episodic memory test that assesses immediate and episodic memory. Variables such as age, sex, and education level can impact performance on this type of memory test, as can cultural differences. Therefore, the purpose of this study was to establish normative data for the story recall subtest of the BEM-144 in the elderly French-Quebec population. METHOD: The normative sample consisted of 260 healthy individuals aged 50-90 years, all from the province of Quebec, Canada. Analyses were performed to estimate the association between age, sex, and education level on one hand, and immediate and delayed recall performance, on the other hand. RESULTS: The results show that all sociodemographic variables are significantly associated with story recall performance. Normative data are proposed in the form of regression equations. CONCLUSIONS: Overall, these norms will be beneficial for the evaluation and detection of episodic memory impairment in middle-aged and older adults.

Normative Data for Healthy French-Speaking Persons Aged 80 Years and Older for the DTLA Language Screening Test.

The Detection Test for Language Impairments in Adults and the Aged (DTLA) is a quick, sensitive, and standardized screening test designed to assess language disorders in adults and elderly people. The test was specifically developed to detect linguistic impairment associated with major neurocognitive disorders. In 2017, we established normative data on 545 healthy individuals between 50 and 80 years old from four French-speaking countries: Belgium, Canada (Quebec), France, and Switzerland. OBJECTIVE: The objective of the present study was to develop norms for the population older than 80 years of age for the DTLA. METHOD: We extend the original normative data to include 149 healthy, community-dwelling, French-speaking adults aged 80 years old and older from the same countries. RESULTS: For the total score of the screening test, we calculated the 5th, 15th, 25th, and 50th percentiles for two education groups. The analyses allowed the identification of cutoff and alert scores based on education level. CONCLUSIONS: With the present study, solid normative data for the DTLA derived from the performance of 694 healthy, community-dwelling adults, and elderly people are now available to clinicians and researchers.

Primary and Secondary Progressive Aphasia in Posterior Cortical Atrophy.

BACKGROUND: Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by a progressive decline in visuospatial/visuoperceptual processing. PCA is accompanied by the impairment of other cognitive functions, including language abilities. METHODS: The present study focused on three patients presenting with language complaints and a clinical profile that was compatible with PCA. In addition to neurological and neuroimaging examinations, they were assessed with comprehensive batteries of neuropsychological and neurolinguistic tests. RESULTS: The general medical profile of the three patients is consistent with PCA, although they presented with confounding factors, making diagnosis less clear. The cognitive profile of the three patients was marked by Balint and Gerstmann's syndromes as well as impairments affecting executive functions, short-term and working memory, visuospatial and visuoperceptual abilities, and sensorimotor execution abilities. Their language ability was characterized by word-finding difficulties and impairments of sentence comprehension, sentence repetition, verbal fluency, narrative speech, reading, and writing. CONCLUSIONS: This study confirmed that PCA is marked by visuospatial and visuoperceptual deficits and reported evidence of primary and secondary language impairments in the three patients. The similarities of some of their language impairments with those found in the logopenic variant of primary progressive aphasia is discussed from neurolinguistic and neuroanatomical points of view.

The Importance of Being Familiar: The Role of Semantic Knowledge in the Activation of Emotions and Factual Knowledge from Music in the Semantic Variant of Primary Progressive Aphasia.

BACKGROUND: The role of semantic knowledge in emotion recognition remains poorly understood. The semantic variant of primary progressive aphasia (svPPA) is a degenerative disorder characterized by progressive loss of semantic knowledge, while other cognitive abilities remain spared, at least in the early stages of the disease. The syndrome is therefore a reliable clinical model of semantic impairment allowing for testing the propositions made in theoretical models of emotion recognition. OBJECTIVE: The main goal of this study was to investigate the role of semantic memory in the recognition of basic emotions conveyed by music in individuals with svPPA. METHODS: The performance of 9 individuals with svPPA was compared to that of 32 control participants in tasks designed to investigate the ability: a) to differentiate between familiar and non-familiar musical excerpts, b) to associate semantic concepts to musical excerpts, and c) to recognize basic emotions conveyed by music. RESULTS: Results revealed that individuals with svPPA showed preserved abilities to recognize familiar musical excerpts but impaired performance on the two other tasks. Moreover, recognition of basic emotions and association of musical excerpts with semantic concepts was significantly better for familiar than non-familiar musical excerpts in participants with svPPA. CONCLUSION: Results of this study have important implications for theoretical models of emotion recognition and music processing. They suggest that impairment of semantic memory in svPPA affects both the activation of emotions and factual knowledge from music and that this impairment is modulated by familiarity with musical tunes.